The Biomolecular Structures Group explores how proteins work at the molecular level, aiming to uncover the mechanisms that drive both their physiological roles and their involvement in disease. Our research bridges chemistry and biology through an interdisciplinary approach.
We investigate how small organic molecules interact with proteins, modulating their structure and function. Many of our targets are linked to pathological conditions, and their study opens opportunities for therapeutic intervention, including rational drug design.
To probe the 3D structures and dynamics of biomolecules, we employ advanced methods such as multidimensional NMR, SAXS, X-ray crystallography, and cryo-EM, complemented by a broad range of biophysical techniques (CD, SEC, DLS, ITC, fluorescence spectroscopy) and kinetic enzymatic assays.
Another major focus of our group is NMR-based metabolomics, combined with multivariate statistical analysis. We apply this approach to food extracts to guarantee origin, quality, and authenticity, and to biological fluids to decipher complex metabolic profiles. These studies help identify biomarkers and metabolic patterns linked to specific physiological states and disease conditions.