{"id":133,"date":"2025-06-26T10:12:05","date_gmt":"2025-06-26T10:12:05","guid":{"rendered":"https:\/\/research.chimica.unipd.it\/nplus\/?page_id=133"},"modified":"2025-10-15T08:53:32","modified_gmt":"2025-10-15T08:53:32","slug":"research","status":"publish","type":"page","link":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<p>The&nbsp;<strong>Biomolecular Structures Group<\/strong>&nbsp;explores how proteins work at the molecular level, aiming to uncover the mechanisms that drive both their physiological roles and their involvement in disease. Our research bridges chemistry and biology through an interdisciplinary approach.<\/p>\n\n\n\n<p>We investigate how small organic molecules interact with proteins, modulating their structure and function. Many of our targets are linked to pathological conditions, and their study opens opportunities for therapeutic intervention, including rational drug design.<\/p>\n\n\n\n<p>To probe the <strong>3D structures and dynamics of biomolecules<\/strong>, we employ advanced methods such as multidimensional <strong>NMR<\/strong>, <strong>SAXS<\/strong>, <strong>X-ray crystallography<\/strong>, and <strong>cryo-EM<\/strong>, complemented by a broad range of <strong>biophysical techniques<\/strong> (CD, SEC, DLS, ITC, fluorescence spectroscopy) and kinetic enzymatic assays.<\/p>\n\n\n\n<p>Another major focus of our group is <strong>NMR-based metabolomics<\/strong>, combined with multivariate statistical analysis. We apply this approach to food extracts to guarantee origin, quality, and authenticity, and to biological fluids to decipher complex metabolic profiles. These studies help identify biomarkers and metabolic patterns linked to specific physiological states and disease conditions.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"height:152px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The&nbsp;Biomolecular Structures Group&nbsp;explores how proteins work at the molecular level, aiming to uncover the mechanisms that drive both their physiological roles and their involvement in disease. Our research bridges chemistry and biology through an interdisciplinary approach. We investigate how small organic molecules interact with proteins, modulating their structure and function. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":211,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-133","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Biomolecular Structures Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Biomolecular Structures Group\" \/>\n<meta property=\"og:description\" content=\"The&nbsp;Biomolecular Structures Group&nbsp;explores how proteins work at the molecular level, aiming to uncover the mechanisms that drive both their physiological roles and their involvement in disease. Our research bridges chemistry and biology through an interdisciplinary approach. We investigate how small organic molecules interact with proteins, modulating their structure and function. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomolecular Structures Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-15T08:53:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1456\" \/>\n\t<meta property=\"og:image:height\" content=\"816\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/\",\"url\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/\",\"name\":\"Research - Biomolecular Structures Group\",\"isPartOf\":{\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png\",\"datePublished\":\"2025-06-26T10:12:05+00:00\",\"dateModified\":\"2025-10-15T08:53:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#primaryimage\",\"url\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png\",\"contentUrl\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png\",\"width\":1456,\"height\":816},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#website\",\"url\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/\",\"name\":\"Biomolecular Structures Group\",\"description\":\"From molecules to protein structures\",\"publisher\":{\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#organization\",\"name\":\"Biomolecular Structures Group\",\"url\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/12\/cropped-logo_v3-scaled-1.png\",\"contentUrl\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/12\/cropped-logo_v3-scaled-1.png\",\"width\":2230,\"height\":2532,\"caption\":\"Biomolecular Structures Group\"},\"image\":{\"@id\":\"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research - Biomolecular Structures Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/","og_locale":"it_IT","og_type":"article","og_title":"Research - Biomolecular Structures Group","og_description":"The&nbsp;Biomolecular Structures Group&nbsp;explores how proteins work at the molecular level, aiming to uncover the mechanisms that drive both their physiological roles and their involvement in disease. Our research bridges chemistry and biology through an interdisciplinary approach. We investigate how small organic molecules interact with proteins, modulating their structure and function. [&hellip;]","og_url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/","og_site_name":"Biomolecular Structures Group","article_modified_time":"2025-10-15T08:53:32+00:00","og_image":[{"width":1456,"height":816,"url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Tempo di lettura stimato":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/","url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/","name":"Research - Biomolecular Structures Group","isPartOf":{"@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#website"},"primaryImageOfPage":{"@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#primaryimage"},"image":{"@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#primaryimage"},"thumbnailUrl":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png","datePublished":"2025-06-26T10:12:05+00:00","dateModified":"2025-10-15T08:53:32+00:00","breadcrumb":{"@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#primaryimage","url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png","contentUrl":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/08\/giovanni06952_chemical_reasearch_in_a_laboratory._Real_camera_749091fc-75cc-4097-8be4-d28c83bb4cf4_1.png","width":1456,"height":816},{"@type":"BreadcrumbList","@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/"},{"@type":"ListItem","position":2,"name":"Research"}]},{"@type":"WebSite","@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#website","url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/","name":"Biomolecular Structures Group","description":"From molecules to protein structures","publisher":{"@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#organization","name":"Biomolecular Structures Group","url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#\/schema\/logo\/image\/","url":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/12\/cropped-logo_v3-scaled-1.png","contentUrl":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/wp-content\/uploads\/2025\/12\/cropped-logo_v3-scaled-1.png","width":2230,"height":2532,"caption":"Biomolecular Structures Group"},"image":{"@id":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/pages\/133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/comments?post=133"}],"version-history":[{"count":7,"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/pages\/133\/revisions"}],"predecessor-version":[{"id":629,"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/pages\/133\/revisions\/629"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/media\/211"}],"wp:attachment":[{"href":"https:\/\/research.chimica.unipd.it\/biomolecular_structures\/index.php\/wp-json\/wp\/v2\/media?parent=133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}