{"id":138,"date":"2025-06-26T10:18:11","date_gmt":"2025-06-26T10:18:11","guid":{"rendered":"https:\/\/research.chimica.unipd.it\/nplus\/?page_id=138"},"modified":"2025-11-17T16:54:28","modified_gmt":"2025-11-17T16:54:28","slug":"graphene-nanotubes-and-carbon-nanostructures-for-tissue-engineering-and-regenerative-medicine","status":"publish","type":"page","link":"https:\/\/research.chimica.unipd.it\/nplus\/index.php\/graphene-nanotubes-and-carbon-nanostructures-for-tissue-engineering-and-regenerative-medicine\/","title":{"rendered":"Graphene, nanotubes and carbon nanostructures for tissue engineering and regenerative medicine"},"content":{"rendered":"\n

Involved people: Enzo Menna<\/strong>, Miriam Mba<\/strong>, Stefania Benazzato<\/p>\n\n\n\n

This research is focused on the design, preparation and characterization of novel polymer nanocomposite (PNC) materials for biomedical applications, based on carbon nanostructures (CNSs) such as carbon nanotubes (CNTs) as nanofillers and biocompatible polymers as a matrix.

We recently demonstrated the possibility of boosting human neuronal cells growth\/differentiation on a nanocomposite free-standing scaffold obtained by efficiently dispersing soluble organic derivatives of CNTs in a poly-L-lactic acid (PLLA) matrix. The electrical resistance of the nanocomposite scaffold resulted more than one order of magnitude lower than that of a pure PLLA scaffold. Cells showed better adhesion<\/strong> to the MWCNT-PLLA scaffold in comparison with pure PLLA and, in addition, they presented a higher total neurite length<\/strong>. Scanning electron microscopy (SEM) images of cells cultured onto the PNC scaffold show an evidently healthy morphology and the outgrowth of<\/a> neurites attaching to the scaffold surface, with intimate contact between this last one and the neuronal membrane (Figure a-b). As a rational extension of this concept, we obtained a nanofibrous matrix, via electrospinning a CNT-PLLA nanocomposite solution, as a biocompatible scaffold for neuronal growth, aimed at better mimicking the extracellular matrix. Indeed, by using this scaffold as support for cells growth, the extension of neurites along the direction of the nanofibers<\/strong> was evidenced (Figure c).<\/p>\n\n\n\n

<\/a>Electrostatic fields generated at the interface  between cells and scaffold might favor  cell growth by tuning their membrane potential.  The inclusion of functionalized MWCNTs<\/strong> in the  insulating PLA matrix resulted in differences in  the surface potential of the fibers<\/strong>.  
SEM, immunocytochemistry, Rt-qPCR,  and electrophysiology revealed that fibroblasts  grown on PLA\/MWCNT reached a healthier state as compared to pure PLA.  <\/p>\n\n\n\n

\"\"\/<\/a><\/figure>\n\n\n\n

A new electroconductive composite scaffold based on oxidized polyvinyl alcohol (OxPVA) and a water soluble a MWCNT derivative<\/strong> (OxPVA+MWCNT-S) was prepared and tested in vivo<\/em><\/strong>.
Neither cytotoxicity nor local signs of inflammation were detected in vitro and after subcutaneous implantation (14 and 42 days), proving composite material biocompatibility. OxPVA+MWCNT-S revealed as promising for future electroconductive conduits for peripheral nerve regeneration<\/strong>.<\/p>\n\n\n\n

Regen. Biomater.<\/em>,\u00a02025<\/strong>, 10.1093\/rb\/rbaf108<\/a>
Small<\/em>,\u00a02025<\/strong>, 21<\/em>, 2504992<\/a>
J. Mater. Chem. B<\/em>,\u00a02025<\/strong>,\u00a013<\/em>, 8105-8120<\/a>
J. Sci.: Adv. Mater. Devices<\/em>,\u00a02024<\/strong>,\u00a09<\/em>, 100762.<\/a>
ACS Appl. Mater. Interfaces<\/em>\u00a02024<\/strong>,\u00a016<\/em>, 3093-3105<\/a>.
<\/a>Nanomaterials<\/em>\u00a02021<\/strong>,\u00a011<\/em>, 404.<\/a>
Nanomaterials<\/em>\u00a02020<\/strong>,\u00a010<\/em>, 415.<\/a>
Mater. Chem. Phys.<\/em>,\u00a02018<\/strong>,\u00a0214<\/em>, 265-276.<\/a>
Nanomedicine<\/em>\u00a02016<\/strong>,\u00a011<\/em>, 1929-1946<\/a>
Nanomed.-Nanotechnol. Biol. Med.<\/em>\u00a02015<\/strong>,\u00a011<\/em>, 621-632.<\/a>
Carbon<\/em>\u00a02015<\/strong>,\u00a095<\/em>, 725\u2013730<\/a>.

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Involved people: Enzo Menna, Miriam Mba, Stefania Benazzato This research is focused on the design, preparation and characterization of novel polymer nanocomposite (PNC) materials for biomedical applications, based on carbon nanostructures (CNSs) such as carbon nanotubes (CNTs) as nanofillers and biocompatible polymers as a matrix. We recently demonstrated the possibility […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-138","page","type-page","status-publish","hentry"],"yoast_head":"\nGraphene, nanotubes and carbon nanostructures for tissue engineering and regenerative medicine - N-Plus Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.chimica.unipd.it\/nplus\/index.php\/graphene-nanotubes-and-carbon-nanostructures-for-tissue-engineering-and-regenerative-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Graphene, nanotubes and carbon nanostructures for tissue engineering and regenerative medicine - N-Plus Research Group\" \/>\n<meta property=\"og:description\" content=\"Involved people: Enzo Menna, Miriam Mba, Stefania Benazzato This research is focused on the design, preparation and characterization of novel polymer nanocomposite (PNC) materials for biomedical applications, based on carbon nanostructures (CNSs) such as carbon nanotubes (CNTs) as nanofillers and biocompatible polymers as a matrix. We recently demonstrated the possibility […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.chimica.unipd.it\/nplus\/index.php\/graphene-nanotubes-and-carbon-nanostructures-for-tissue-engineering-and-regenerative-medicine\/\" \/>\n<meta property=\"og:site_name\" content=\"N-Plus Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-17T16:54:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wwwdisc.chimica.unipd.it\/enzo.menna\/images\/OxPVA_01_summary_01s.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/research.chimica.unipd.it\/nplus\/index.php\/graphene-nanotubes-and-carbon-nanostructures-for-tissue-engineering-and-regenerative-medicine\/\",\"url\":\"https:\/\/research.chimica.unipd.it\/nplus\/index.php\/graphene-nanotubes-and-carbon-nanostructures-for-tissue-engineering-and-regenerative-medicine\/\",\"name\":\"Graphene, nanotubes and carbon nanostructures for tissue engineering and regenerative medicine - 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