Hybrid Molecules and Materials

Hybrid Molecules and Materials

The research group primarily focuses on the design and characterization of hybrid molecular systems and nanostructures for applications as catalytic and therapeutic agents. These systems include polyoxometalates, metal clusters, oxides, halloysite nanotubes and metal nanoparticles. In addition, the group develops hybrid materials and composites following circular economy principles, aiming to valorize renewable resources or waste materials.

1. Hybrid polyoxometalates (POMs) are designed, synthesized, and thoroughly characterized. Through tailored functionalization with peptides, they can specifically target overexpressed receptors on cancer cells. Selected POMs exhibit significant anticancer activity, primarily through the induction of apoptotic mechanisms. Moreover, their functionalization is essential to enhance cellular internalization and improve selectivity toward cancer cells.
2. Metal complexes are prepared using ligands designed to act as chelators or to form dinuclear complexes with antioxidant activity. These systems can modulate the redox behaviour of metal ions such as Cu²⁺, reducing their pro-oxidant character and, in some cases, conferring antioxidant properties. Moreover, polyoxometalates can act as antioxidants against reactive species and be employed to protect biomolecules and cells from oxidative stress.
3. Deep eutectic solvents (DESs) are applied to the treatment of complex matrices, including lithium-ion battery black mass for metal ion extraction and post-consumer textiles for cellulose recovery. In each case, tailored approaches are developed for the recovery, purification, and valorisation of the extracted materials.